IVF transplantation four times did not connect to the bed considered by bad mood, endometrial inflammation, embryo abnormalities and other conditions caused by the general can be adjusted through the state of mind, taking medication, do the third generation of IVF and other ways to improve the bed situation. 1. Adjusting the state of mind: Emotions can also affect the success rate of IVF. If the patient is in a long-term low mood, anxiety and tension, it will cause abnormal hormone secretion, leading to endocrine disorders, which will affect the embryo’s implantation. In this case, it is necessary to adjust the emotions, relax and keep optimistic to promote the embryo’s implantation. 2. Taking medication: If the patient suffers from endometritis, the endometrium will be congested and edematous, and infiltrated with inflammatory cells, which will also lead to the difficulty of embryo implantation. In this case, you can take anti-infective medication such as cefaclor tablets and levofloxacin hydrochloride capsules to control the endometrial inflammation, so as to avoid affecting the implantation of the embryo. 3. Third generation IVF: chromosomal abnormality of embryo can also lead to embryo not implanting, in this case, you can apply for third generation IVF with complete documents and in line with the situation of multiple failed IVF and family genetic disease, etc., to screen out healthy embryo implantation through genetic analysis and diagnosis before implantation of embryo, in order to improve the situation of difficult to implant the embryo. If IVF fails for many times, you should seek medical treatment in time to clarify the cause of failure, and then the doctor will formulate an individualized treatment plan to reduce the adverse effects of the disease.