High prealbumin suggests the possible presence of Hodgkin’s lymphoma, excessive protein diet, and recovery from acute hepatitis. Prealbumin, also known as pre-serotonin, is synthesized by hepatocytes, has a molecular weight smaller than that of serotonin, and is located in front of the serotonin band in the electrophoretic pattern, hence the name pre-serotonin. The serum concentration of prealbumin is influenced by liver function and nutritional status. Thus high prealbumin can be seen in recovery from acute hepatitis or in patients with liver damage after abstinence from alcohol, but also in the context of an excessive protein diet, as may be the case in some patients with nephrotic syndrome. High prealbumin is also seen in Hodgkin’s lymphoma and is associated with inhibition of prealbumin degradation by sialic acid on the surface of Hodgkin’s lymphoma cells. It is recommended that those with prealbumin abnormalities have regular follow up visits, medical appointments, and further investigations and treatment as prescribed by the doctor.