Atherosclerotic plaque formation of the right subclavian artery is mostly due to the presence of hypertension, smoking, obesity, diabetes and other undesirable triggering factors, resulting in non-inflammatory, proliferative changes in the right subclavian artery, appearing in the lumen of the blood vessel becomes smaller, triggering a series of uncomfortable symptoms. Right subclavian artery atherosclerotic plaque formation is the result of a variety of factors, mostly in obesity, smoking, alcohol, hypertension, diabetes and other people. When patients have the above adverse factors, it can lead to the accumulation of smooth muscle cells, T lymphocytes and macrophages in the arterial vessels over time, which further leads to the accumulation of lipid substances and the formation of atherosclerotic plaque. Atherosclerotic plaque formation in the right subclavian artery may lead to dislodgement of the plaque, insufficient blood supply to the right upper extremity and severe pain. When the right subclavian artery atherosclerotic plaque is dislodged, it may enter the lungs and heart with the blood flow, and the patient may also experience myocardial infarction and pulmonary embolism. The causes of atherosclerotic plaque formation in the right subclavian artery are complex and influenced by many factors. In daily life, it is recommended to avoid smoking, drinking and other bad habits and behaviors.