Adverse reactions to varicella vaccine are mainly categorized into local adverse reactions such as redness, swelling and pain at the vaccination site and systemic adverse reactions such as fever and rash. Chickenpox is a kind of acute infectious disease that occurs in children and immunocompromised people, caused by varicella-zoster virus, and vaccination is the most effective way to prevent it. Currently, the vaccine injected in China is live attenuated varicella vaccine, which has the advantages of high safety and mild adverse reactions, but there are also serious adverse reactions, so it is mostly recommended to stay for 30 minutes after vaccination. Local adverse reactions of varicella vaccine include erythema, swelling, itching, pain and hardness at the vaccination site. In general, mild symptoms can be observed without treatment. For severe symptoms, oral medication, cold compresses and other symptomatic treatment can be used. Systemic adverse reactions to varicella vaccine include fever, rash, and allergy. The mild symptoms mentioned above can usually subside on their own within a short period of time and do not require special treatment. If there are serious symptoms such as persistent high fever and anaphylaxis, the patient should go to a regular medical institution in time and actively cooperate with the relevant diagnosis and treatment, so as to avoid delaying the condition.