Strenuous exercise, taking certain drugs, cardiovascular and cerebrovascular diseases, dermatomyositis, etc. can cause elevated creatine kinase, which can be treated with medication and other methods. 1. Non-disease factors: creatine kinase can be elevated after prolonged strenuous exercise. It is recommended to take measurement again after a few days of rest, and creatine kinase can generally be reduced to normal level. Taking drugs such as dexamethasone and clofibrate can also cause an increase in creatine kinase. It is recommended to stop taking these drugs or to change to other drugs under the guidance of a doctor. 2. Disease factors: cardiovascular and cerebrovascular diseases can lead to elevated creatine kinase, such as viral myocarditis, furosemide, nitroglycerin, dobutamine and other medications can be used to improve cardiac function under the guidance of a doctor. Surgery may be used if medication is not effective. Dermatomyositis may also cause elevated creatine kinase and is recommended to be treated with prednisone, methotrexate, cyclophosphamide, intravenous gammaglobulin, tofacitibine, and other medications under the supervision of a doctor. There are many factors that can cause elevated creatine kinase, so it is recommended to go to the hospital in time to find out the cause and treat it promptly.