Generally speaking, it is unlikely that the hepatitis B surface antigen of more than 120 will turn negative. The hepatitis B antigen turning negative indicates that hepatitis B has been completely cured, but hepatitis B is very difficult to cure, and the possibility is low. Hepatitis B surface antigen is an important marker in the results of serological testing of hepatitis B virus, is the shell protein of the hepatitis B virus, itself is not contagious, often accompanied by the presence of the hepatitis B virus, is the standard of judgment of the hepatitis B virus has been infected; it can be present in the patient’s blood, saliva, breast milk, sweat, tears, nasopharyngeal secretions, semen and vaginal secretions. The probability of conversion of hepatitis B surface antigen is usually less than 10%. Hepatitis B patients can take Fuenticavir, Tenofovir and other medications under the guidance of a doctor to treat hepatitis B. After the symptoms are relieved, the value of hepatitis B surface antigen may drop or even become negative. When hepatitis B surface antigen turns negative, it basically means that hepatitis B is cured, indicating that the hepatitis B virus in the patient’s body has basically been cleared. When the hepatitis B surface antigen is more than 120, it is necessary to consult the doctor in time to receive treatment, so as not to delay the condition.