Blood creatinine 100μmoI/L, urinary occult blood 2+ may be caused by pathological factors such as urinary stones, tumors, chronic kidney disease, or physiological factors such as strenuous exercise. 1.Pathologic factors (1) urinary stones: stones may be in the kidney, ureter, bladder and other parts of the body, if the stone is large obstruction for a long time, it can cause renal function damage to appear blood creatinine increase, and the stone can scratch the urethra bleeding, thus appearing in the urine occult blood 2 +, can be used to medication, extracorporeal lithotripsy, surgical treatment. (2) Urological tumors: when there are bladder tumors, kidney tumors, can affect renal function, tumor compression of peripheral tissues can cause bleeding, urological ultrasound and other tests can be a clear diagnosis, early surgical resection, and if it is a malignant tumor also need to combine with radiotherapy to prevent recurrence and metastasis. (3) Chronic kidney diseases: common chronic kidney diseases include chronic nephritis, hypertensive nephropathy, membranous nephropathy, etc., which can cause creatinine increase and urinary occult blood, and need to improve the urine erythrocyte morphology examination, as well as urinary ultrasound, renal puncture and other tests to clarify. 2. Physiological factors: Physiological factors such as strenuous exercise can lead to abnormal creatinine and occult blood in urine, which can be normalized after appropriate rest. It is recommended that patients go to the hospital, complete the examination under the guidance of the doctor, clarify the cause of the disease, and follow the doctor’s instructions to standardize the use of medication or surgical treatment, to avoid blindly using their own medication.