Before discontinuing tacrolimus for rosacea, you can determine the skin recovery, adjust the dosage gradually, and be guided by a professional doctor on the discontinuation plan. 1. Determine the skin recovery: Before stopping tacrolimus for rosacea, you can determine the skin recovery, make sure that the rosacea on the skin has reached a stable state, you can continue treatment without tacrolimus. 2. Gradual: When stopping tacrolimus for rosacea, it is not necessary to stop using tacrolimus completely at the beginning, but to gradually reduce it by half, then by one-third, one-fourth, until completely stopping the drug, there needs to be a process of stopping the drug. 3. Doctor’s guidance: discontinuing tacrolimus for rosacea may result in recurrent rosacea, skin erythema, itching and other withdrawal reactions, so discontinuing tacrolimus should be guided by a doctor for a specific program to reduce the chances of withdrawal reactions. It is recommended that patients with rosacea should not blindly discontinue tacrolimus and need to follow their doctor’s instructions.