Smooth muscle tumor CD34+ is not malignant. Smooth muscle tumors are tumors originating from smooth muscle tissue and are generally benign. They can be classified as cutaneous smooth muscle tumors, gastric smooth muscle tumors, uterine smooth muscle tumors, esophageal smooth muscle tumors, etc. They can be cured by surgery. CD34 belongs to a phenotype of immunohistochemistry, which is mainly used for the pathological diagnosis of certain tumors, and CD34+ of smooth muscle tumor does not mean that smooth muscle tumor is malignant. It is recommended that patients go to regular hospitals in time to get a clear diagnosis and receive standardized treatment.