The presence of paroxysmal vague pain in the location of the ascending colon may be related to appendicitis, Crohn’s disease, colitis, etc.. 1. Chronic appendicitis: due to its structure, it is prone to obstruction or bacterial invasion, leading to inflammation of the appendix. This causes pain in the appendix, but because it is connected to the colon, chronic appendicitis may also cause pain in the ascending colon. 2. Crohn’s disease: It may be closely related to cellular immunity, humoral immunity, measles virus infection, genetics and other factors. When the lesion is in the ascending colon, there will also be paroxysmal pain. 3. Ulcerative colitis: it can be caused by the interaction of bacteria, protozoa or intestinal microecology and other factors, causing damage to the intestinal mucosal barrier, leading to persistent inflammatory damage of the intestinal mucosa. When it involves the ascending colon, paroxysmal occult pain occurs. Ascending colon location paroxysmal pain can also be seen in other causes, it is recommended to timely consult a doctor, follow the doctor’s instructions for relevant examinations, with the help of the doctor to clarify the cause, and targeted treatment or therapy.