There is no record of Pan Huang San in traditional Chinese medicine, but San Huang San is recorded in Bijie Qianjin Yaofang, You’s Throat Secretary, Pediatric Medicinal Evidence Direct Recipe, Ulcer Doctor Daquan, and Miscellaneous Diseases Source and Flow Rhinoceros Candle, with different compositions and main treatments. The composition of San Huang San in Biquan Qian Jin Yao Fang (备急千金要方) is Da Huang (大黄), Huang Lian (黄黄连) and Huang Qin (黄芩), which is mainly used for the treatment of nosebleed, jaundice, yellow eyes and yellow skin. The composition of San Huang San in You’s Secretary of Laryngeal Medicine is raw rhubarb, raw Pu Huang, turmeric, ice tablet and musk, which mainly treats redness, swelling, heat and pain of the skin of the neck, face and submandibular area, and pediatric dengtoxin (an acute infectious disease, which can be seen as reddening of the skin like paint, and blotchy rashes) and so on. The composition of San Huang San in “The Complete Ulcer Doctor” is composed of Radix Rehmanniae Praeparata, Rhizoma Pinelliae, Rhizoma Oxalis, and Porphyra Bicarbonate, which is mainly used for the treatment of redness, swelling, and heat pain of the head and face, and pediatric dengue. The composition of San Huang San in “Miscellaneous Diseases Source and Flow Rhinoceros Candle” is Xionghuang, sulfur, Huangdan, Tennansing, withered alum, mithrax, mainly for the treatment of vitiligo and so on. If there is any discomfort, please consult a doctor in time and use the medicine after diagnosis and identification by a physician.