Patients with small and itchy bubbles on the eyelids may be caused by herpes simplex, herpes zoster, eczema and other factors. 1. Herpes simplex: If infected with herpes simplex virus, it may lead to blisters on the skin of the eyelids and other parts of the body, which rupture and form ulcers, usually accompanied by pain and itching. 2. Herpes zoster: If a patient is infected with herpes zoster virus, it may lead to a rash on the skin of the eyelids and other parts of the body, and before the rash appears, tingling, burning sensation, itching and other discomforts around the affected nerves may appear. 3. Eczema: If the patient’s eyes come into contact with allergens such as pollen, dust mites, animal hair, etc., eczema may be induced, which may lead to pimples, papules, redness, itching and other discomforts in the skin around the eyes. It is recommended that patients with small bubbles on the eyelids and significant itching should seek prompt medical attention to assess their condition and follow the doctor’s instructions for treatment.