Liver failure usually requires about 3 to 5 blood changes, depending on the patient’s degree of recovery. For the symptoms of liver failure, the effect of drug treatment is not good, and the coagulation function is poor, the condition is also more serious, the detoxification function of toxic substances will also be reduced, and the liver function and coagulation function continue to deteriorate. Only through blood exchange to reduce liver damage, effective supplementation of coagulation factors, usually in about 3~5 times, if the blood exchange has no effect, if necessary, to do artificial liver or liver transplantation, in order to alleviate the condition. Liver failure patients should pay more attention to rest, and pay attention to a balanced diet, and regularly go to the hospital for review, better understanding of the condition, to prevent the recurrence of liver failure.