Pimples on the sides of the shoulders can be caused by acne, folliculitis, eczema or common warts. Depending on the situation, topical medication, medication or physical therapy can be used. 1. Acne: Due to endocrine disorders and other reasons, the sebaceous ducts and follicles in the skin are blocked and infected by Propionibacterium acnes, causing acne and the symptom of pimples on both sides of the shoulders. Antibacterial drugs such as benzoyl peroxide, clindamycin and fusidic acid are commonly used, which can kill Propionibacterium acnes and have anti-inflammatory effects. 2. Folliculitis: due to scratching or friction stimulation, damage to the surface layer of the skin on both sides of the shoulder, by the invasion of purulent bacteria infection, causing folliculitis leading to the symptoms of localized rash. It can be treated by topical application of sildenafil ointment. 3. Eczema: Eczema on both sides of the shoulders can be caused by allergic reactions and other factors, resulting in symptoms of rashes on both sides of the shoulders. Eczema can be treated by taking antihistamines, such as levocetirizine tablets and loratadine tablets. 4. common warts: in the case of immunity decline, low-risk human papilloma virus invades the skin on both sides of the shoulder, resulting in abnormal proliferation of local stratum corneum cells, causing common warts, which will appear in the local pimples of symptoms. Physical therapy can be taken, including freezing, scraping, laser and so on are effective treatment methods. It is recommended that the patient go to the hospital in time, in the doctor’s diagnosis to clarify the cause of the disease, to take different treatments, can not be used recklessly in order to avoid aggravation of the condition.