It is possible to reverse diabetes, so it is possible to be cured of diabetes, but even after reversal blood glucose needs to be monitored. The mechanisms of reversal are mainly restoration of the individual’s fat threshold, release of glucolipid toxicity or improvement of gut hormones and gut flora, allowing the dedifferentiated pancreatic B-cells to regain their ability to secrete insulin. Diabetic patients can promote normalization of their diabetic metabolic state through diet and exercise therapy. Scientific weight loss and good weight management are also needed. Intensive hypoglycemic therapy with hypoglycemic drugs or insulin can be applied. Metabolic surgical treatment can affect food intake, digestion and absorption, thus achieving weight loss and improving the efficacy of metabolic abnormalities. Pancreas transplantation or islet transplantation is mainly used for patients with type 1 diabetes. It is important to note that not all diabetes can be reversed, and regular review is required after the condition is reversed. It is recommended that diabetic patients seek timely hospital consultation and standardized treatment under the guidance of doctors.