During quadruple therapy means that during treatment with quadruple drugs, consumption of foods containing alcohol, strong stimulants, and hard texture is not recommended. Quadruple therapy refers to the use of a proton pump inhibitor plus a bismuth agent plus two antibiotics for anti-Helicobacter pylori infection treatment, commonly used drugs include omeprazole, bismuth potassium citrate, amoxicillin, clarithromycin and so on. During the treatment period, more attention should be paid to the food containing alcohol is not recommended to eat, such as alcohol-centered chocolate, tofu milk, etc., because alcohol will destroy the mucosal barrier of the digestive tract, damage the epithelial cells and blood vessels, which in turn aggravates the condition. Sometimes it also affects the metabolism of alcohol in the body, leading to the accumulation of ethanol and causing disulfiram-like reactions. In addition, try not to eat foods that are irritating and too hard, such as: chili peppers and fried foods. Because the patient himself gastrointestinal mucosa will exist lesions, and after eating these foods may increase the stimulation of the gastrointestinal mucosa, leading to nausea, vomiting, abdominal pain and other abnormal phenomena. During the treatment period of quadruple therapy, more attention should be paid to a light, easily digestible diet, the choice of medication also needs to be sufficient amount, full course of treatment, and generally need to be re-examined after stopping the drug to determine the effectiveness of the treatment.