Symptoms of advanced stage of lymphoma mainly include fever, emaciation, anemia, and the appearance of organ metastasis will have corresponding clinical manifestations. Treatment is mainly based on chemotherapy and targeted therapy. The tumor load of lymphoma in late stage is relatively large, and the clinical symptoms are more obvious, such as fever, emaciation, anemia and other systemic manifestations, so it is easier to diagnose, but the treatment effect is not ideal. The appearance of organ metastasis will also have corresponding manifestations, for example, liver metastasis will lead to right upper abdominal pain, loss of appetite, even jaundice; lung metastasis will lead to cough, chest pain, blood in sputum and so on due to the stimulation of bronchus or pleura. The treatment plan for advanced lymphoma is mainly chemotherapy and targeted therapy, and active treatment can alleviate the patient’s symptoms and prolong the survival time.