Uremia late critical condition, there will be water, electrolyte metabolic disorders, cardiovascular system performance, gastrointestinal symptoms. 1. Water and electrolyte disorders: including metabolic acidosis, water and sodium metabolism disorders, potassium metabolism disorders, calcium and phosphorus metabolism disorders, magnesium metabolism disorders and so on. 2. Cardiovascular system manifestations: including hypertension and left ventricular hypertrophy, heart failure, uremic cardiomyopathy, pericardial lesions, vascular calcification and atherosclerosis. 3. Gastrointestinal symptoms: mainly lack of appetite, nausea and vomiting, and urine odor in the mouth. Patients with advanced uremia should go to the hospital in time for timely treatment under the guidance of professional physicians.