If bile duct cancer has spread to blood vessels, radiotherapy, chemotherapy, targeted therapy and supplemental nutrition should be given. When bile duct cancer spreads to blood vessels, it means that distant metastasis has occurred. When malignant tumor has metastasis, generally the possibility of recovery is small, and at this time, there is no chance of radical surgery, so the progress of the disease can be slowed down by means of radiotherapy, chemotherapy, or targeted therapy as far as possible. When cholangiocarcinoma has metastasis, it means that the cancer has entered the advanced stage, at this time, the nutritional consumption of the body is very great, and it is easy to have water-electrolyte disorders, malnutrition, and so on, and it is also easy to be infected, therefore, it is necessary to give nutritional supportive treatment, such as giving fat milk, and supplementing sodium ion or potassium ion, etc. In normal times, patients should pay attention to resting more. Patients should also pay attention to rest more, do not exert themselves and pay attention to light diet. When cholangiocarcinoma spreads to blood vessels, patients should go to the hospital immediately and actively cooperate with the treatment under the doctor’s guidance.