High thyroglobulin antibodies are indicative of autoimmune thyroid disorders, such as Graves’ disease and Hashimoto’s thyroiditis, which can affect thyroid hormone levels, leading to hypothyroidism or hyperthyroidism, and can be life-threatening if not treated properly. Thyroglobulin antibodies are a type of glycoprotein in the serum. Normal people have low or no levels of thyroglobulin antibodies in their serum, but if they are elevated, it suggests that there may be autoimmune thyroid disorders, such as Graves’ disease, Hashimoto’s thyroiditis, and so on. In Graves’ disease, symptoms of hyperthyroidism, such as palpitations, fatigue, weight loss, diarrhea, insomnia, etc., and in Hashimoto’s thyroiditis, symptoms of hypothyroidism, such as bradycardia, weight gain, loss of concentration and memory, abdominal distension, constipation, etc., are present; the above symptoms may affect the patient’s daily life, but the symptoms can be improved with standardized treatment. Failure to standardize treatment may lead to serious complications such as thyroid crisis and coma with mucous edema, which may even threaten the patient’s life. Patients with high thyroglobulin antibodies are advised to go to the hospital and ask the doctor to make a judgment.