Benadryl hydrochloride tablets and Irbesartan these two antihypertensive drugs can not be compared, it is recommended that the doctor comprehensive assessment of the condition, choose the appropriate antihypertensive drug treatment is better. Usually for patients with hypertension or congestive heart failure, Benadryl hydrochloride tablets can be chosen as prescribed by the doctor for treatment, which can reduce blood pressure or relieve the uncomfortable symptoms of heart failure in a short period of time; for patients with hypertension combined with type 2 diabetes mellitus, Irbesartan can be taken as prescribed by the doctor for treatment with the relevant dosage, which can achieve the desired therapeutic effect. Secondly, Benadryl hydrochloride tablets may cause dizziness, fatigue, drowsiness and other discomforts after use, therefore, for driving vehicles, operating machinery and other special personnel, need to be used with caution under the guidance of a doctor; for the drug components of those who are allergic to the drug, angioneurotic edema is prohibited, and the use of the drug process also need to monitor blood pressure. And Irbesartan in the use of drugs may appear postural vertigo, hypotension, renal impairment and other discomforts, therefore, in the process of using the drug should pay attention to blood urea nitrogen, serum creatinine and other indicators of the monitoring; for the drug components of those who are allergic to the prohibited, pregnant women, the elderly and other special people, need to be guided by a doctor to use the drug. To summarize, the above two drugs have the effect of lowering blood pressure, but their indications are different; therefore, it is recommended to decide the specific dosage and study the precautions after a comprehensive assessment of the condition by a doctor.