Coughing up yellow sputum for a long time and taking medication without effect may be stubborn infection is not cured, common such as bronchiectasis, lung abscess and other diseases, but also need to pay attention to the use of drug resistance or the emergence of new infections. Bronchial dilatation infection is often not easy to completely control the inflammation, there can be a long-term cough yellow sputum, bronchial dilatation in the case of co-infection, according to the results of sputum culture and drug sensitivity test results of the selection of sensitive antibiotics, such as cefoxitin, amoxicillin clavulanic acid potassium and other drugs treatment. Lung abscess treatment course is relatively long, can also be manifested as long-term cough yellow sputum, mostly due to inhalation factors, often combined with anaerobic infections, can use metronidazole, tinidazole anti-anaerobic treatment, in the antibiotic treatment at the same time, to promote the sputum discharge is also a very important part of the special position may be required to drain the sputum. In addition, it is also necessary to pay attention to the use of drugs whether there is drug resistance, which may result in poor therapeutic effect; or during the treatment of a new pathogen infection, may also cough yellow sputum. When the long-term cough yellow sputum medication is not effective, it is recommended to go to the hospital for further examination to clarify the cause of the disease before treatment, so as not to blindly use drugs to delay the condition.