Taking two eszopiclone tablets and still not being able to sleep may be related to drug resistance, taking excitatory drugs, eating excitatory food and other reasons. 1. drug resistance: if the long-term use of eszopiclene tablets, the patient has developed drug resistance, it will lead to the phenomenon of taking or not being able to sleep. 2. Taking excitatory drugs: If the patient takes eszopiclone at the same time, but also take other excitatory drugs, such as theophylline, glucocorticoids, etc., will antagonize the role of eszopiclone’s sleep-aiding effect, which will lead to take or can not sleep. 3. Eating excitatory food: for example, drinking coffee, strong tea and other excitatory food, will make the brain in a high-pitched, excited state, will lead to take eszopiclone after still can not sleep. Adverse reactions include dry mouth, drowsiness, dizziness and weakness. It is contraindicated in people who are allergic to the product and the ingredients contained in it, patients with hepatic or renal impairment, patients with myasthenia gravis, and patients with acute or easy-to-occur closed-angle glaucoma. It is not suitable for pregnant and lactating women, children under 18 years old. It is recommended that patients take medication under the guidance of a doctor, and can listen to some light music to relax, which can help improve the symptoms.