Pleural calcification is often a lesion that heals after the pleura has suffered an inflammatory injury. Calcium salts may be deposited in the presence of organized blood clots or caseous necrotic material in the pleural cavity, forming pleural calcification. Small areas of pleural calcification often do not cause significant harm, while large areas of pleural calcification can affect respiratory function. Normally, the pleura forms the pleural cavity, which maintains negative pressure to help the lungs expand and thus facilitate breathing. Small areas of pleural calcification often do not cause significant harm. When a large area of pleural calcification occurs or the calcification foci are large, it can compress the lung tissue and affect the normal expansion of the lungs, which in turn affects the patient’s respiratory function, and the patient may experience symptoms such as fatigue, shortness of breath, and dyspnea. The causes of pleural calcification are many, including tuberculous pleurisy, purulent pleurisy, pleural mesothelioma, etc. Patients should go to the hospital in time, complete the examination, and give targeted treatment after clarifying the cause.