Stage IV nasopharyngeal cancer represents that nasopharyngeal cancer has now developed into advanced stage. Stage IV nasopharyngeal cancer belongs to advanced nasopharyngeal cancer, with a wide range of lesions, which usually invade intracranial, hypopharyngeal, orbital and parotid glands, and may also invade intrapterygoid and extrapterygoid muscles, and unilateral or bilateral metastasis of cervical lymph nodes may also occur. When nasopharyngeal cancer develops into advanced stage, radiotherapy should be carried out as soon as possible to inhibit the cancer cells, and cisplatin plus fluorouracil can be chosen in chemotherapy, which can improve the survival time of the patients at the same time with radiotherapy. The condition of nasopharyngeal cancer stage IV is relatively serious, after the onset of the disease, it is recommended to consult otorhinolaryngology and oncology department in time, and fiberoptic nasopharyngeal laryngoscopy, nasopharyngeal enhancement CT, nasopharyngeal and head enhancement magnetic resonance imaging, ultrasound of cervical lymph nodes, bone scanning and other related examinations can be done. It is more important to determine the primary tumor foci and distant metastatic foci for the development of treatment plan.