High creatine kinase isoenzyme with chest pain may be due to chest trauma or myocardial injurious disease. Patients should take medication according to the doctor’s advice after going to the hospital for further examination. 1. Chest trauma: If the high creatine kinase isoenzyme and chest pain are caused by injury to the muscles of the chest, some painkillers, such as aspirin, can be taken under the advice of the doctor. 2. Myocardial injurious disease: If the patient has high creatine kinase isoenzyme and chest pain caused by myocardial injurious disease such as myocardial ischemia, myocardial infarction, etc., he/she should undergo further examination to clarify the degree and location of myocardial injury and to determine whether surgical treatment is needed. Medications can be aspirin, tegretol, prilosec and sartans. It is recommended that if there are abnormalities of unsuitable test indicators, it is recommended to consult a doctor as soon as possible to avoid delaying the condition.