Domperidone and omeprazole can be taken together, there are no contraindications between the two, and will not cause adverse reactions to the body. Domperidone belongs to the gastric power drug, clinically used to treat indigestion, nausea, vomiting, abdominal distension and other symptoms. Omeprazole belongs to a proton pump inhibitor, can inhibit gastric acid secretion, mostly used in the treatment of gastric ulcers, reflux esophagitis, Zhuo – Ai syndrome and other aspects. Both are used to treat digestive disorders, so they can be taken together without drug side effects. Domperidone is contraindicated for allergy, pheochromocytoma, breast cancer, mechanical intestinal obstruction, etc. It is used with caution in patients with hepatic impairment, pregnant women, children, the elderly, etc. Occasionally, headache, insomnia, nervousness, dizziness and other symptoms are seen. Omeprazole is contraindicated for allergy, severe renal insufficiency and infants and children, should not be combined with atazanavir, pregnant and lactating women should be cautious, adverse reactions are headache, diarrhea, nausea and so on. Drugs need to be taken under the guidance of a doctor, do not use drugs privately, if there is discomfort during the medication, you need to stop the drug in time to seek medical attention.