A 24-hour urine protein quantification of 8g is more serious, suggesting possible nephrotic syndrome. 24-hour urine protein quantitative greater than 3.5g, diagnosed as massive proteinuria, is common in nephrotic syndrome. Clinical manifestations of nephrotic syndrome are massive proteinuria, hypoalbuminemia, edema, and hyperlipidemia. Nephrotic syndrome can lead to complications of infection, renal vein thrombosis, acute kidney injury, and in severe cases, renal failure, which should be treated in time to control disease progression. Treatment includes diuresis to reduce swelling (e.g. furosemide), application of glucocorticoids (e.g. prednisone) and cytotoxic drugs (e.g. cyclophosphamide) for immunosuppressive therapy. All of the above drugs should be used according to the doctor’s prescription, do not self-medicate. There may be other reasons for the 24-hour urine protein quantitative 8g, it is recommended that the patient go to the hospital in time to clarify the cause of the disease, under the guidance of the doctor for standardized treatment.