Scleroderma often refers to clinical scleroderma, which can be categorized into limited scleroderma and systemic scleroderma, and is treated with different drugs according to different types, such as glucocorticoids, anti-sclerosis, immunosuppressant therapy and so on. 1. Limited scleroderma: in the early stage of the disease, patients can be treated with glucocorticosteroid drugs, such as dexamethasone, etc.; for linear scleroderma, especially for hip joints, we need to pay attention to the joint activities, along with a variety of physical therapy in order to prevent spasticity and limitation of joint activities. 2. Systemic scleroderma: it can be treated by general treatment, vasospasm treatment, anti-sclerosis treatment, glucocorticoid, immunosuppressant and so on. General treatment: patients should pay attention to avoid excessive tension and mental stimulation, pay attention to keep warm, quit smoking, avoid trauma and so on. Vasospasm treatment: Calcium channel blockers such as nifedipine as well as alpha receptor blockers such as tolazoline can be used for rational treatment. Anti-sclerosis treatment: colchicine can be used to inhibit local collagen production or sludge; also can be used to inhibit the activity of fibroblasts, soften the connective tissue. Glucocorticoids: only for inflammatory myopathy and arthritis where the disease progresses more rapidly and the inflammatory damage is more obvious, such as commonly used prednisone, etc., but avoid long-term use. Immunosuppressants: methotrexate has a certain therapeutic effect on early diffuse skin lesions; cyclophosphamide can treat interstitial lung disease in addition to skin lesions. The appearance of scleroderma should be timely consultation, standardized treatment under the guidance of the doctor, drugs need to be used in accordance with medical advice.