There is no such statement as “what is the best medicine for bone pain in advanced stage of lung cancer”. Bone pain in advanced stage of lung cancer is considered to be bone metastasis, which can be relieved by chemotherapy, targeted therapy, immunotherapy and so on. After advanced lung cancer patients have bone metastasis, they are not suitable for surgical treatment, and need to consider using chemotherapy drugs such as cisplatin, carboplatin, vincristine, etc. For lung cancer patients with sensitive driver gene mutation, they can also be treated with targeted drugs such as gefitinib, ectinib, etc. Pembrolizumab, etc. can also be used. Immunotherapy drugs such as pembrolizumab can also be used for treatment. In addition, if the pain is severe, it can be treated with painkillers such as morphine and tramadol. Drugs such as zoledronic acid can also be used to inhibit bone destruction and reduce pain. All drugs should be used under the guidance of a doctor, and regular monitoring of adverse reactions should be carried out during the use of medication, so as to avoid delaying the condition.