Infants with chromosomal abnormalities are usually prone to miscarriage around the third trimester, with the timing varying depending on the condition of the organism. Chromosomal abnormalities have a greater impact on the growth and development of the fetus, causing it to stop naturally during development, often requiring the mother to terminate the pregnancy early. Chromosomal abnormalities are usually due to genetic, physical, chemical and biological factors that affect fetal growth and development, and can cause more serious harm to the fetus as well as to the pregnant woman, usually around the third trimester of pregnancy will be miscarried. It is recommended that women undergo regular checkups during pregnancy to detect problems and intervene in a timely manner. Problems caused by chromosomal abnormalities should be terminated in a timely manner in order to avoid other serious effects.