Whether to choose Archie or Cephalosporin for children with fever needs to be analyzed according to the child’s age, clinical symptoms, laboratory tests and other comprehensive analysis. Children with fever, if the blood analysis suggests that white blood cells, C-reactive protein and other indicators of inflammation are elevated, most often consider bacterial infections, in the clear pathogenesis suggests that gram-positive cocci choose the first generation or the second generation of cephalosporins, gram-negative bacilli choose the third or fourth generation of cephalosporins anti-infection. Children over five or six years of age with fever, white blood cells and CRP are normal, and the child with a dry cough, need to pay attention to mycoplasma infection, or laboratory tests to clarify mycoplasma infection, preferred azithromycin treatment is more targeted. Children with fever can not be careless, if the wrong choice of drugs, will prolong the disease or aggravate the lesions for no reason, it is recommended to use drugs under the guidance of a professional physician.