Walking pain in the area of the fifth metatarsal tuberosity may be caused by joint muscle strain, poor blood circulation, gout and other factors. 1. Joint muscle strain: If the patient stands and walks for a long time, performs sports and exercises for a long time, or overly exerts himself/herself to bear weight, it will lead to joint muscle strain, and when the muscles are strained, walking pain in the fifth metatarsal tuberosity may occur. 2. Poor blood circulation: Poor blood circulation may occur due to increased blood viscosity, narrowing or blockage of blood vessels, resulting in slow blood flow and poor blood circulation, which may be the cause of walking pain in the fifth metatarsal tuberosity. 3. Gout: Gout is caused by purine metabolism disorders or uric acid excretion disorders, which can cause acute and chronic inflammatory damage to articular cartilage, bone and kidney. Therefore, patients with gout may experience walking pain in the area of the fifth metatarsal tuberosity. When the patient feels walking pain in the area of the fifth metatarsal tuberosity, it is recommended to consult a doctor in time, and under the guidance of the doctor to carry out relevant examinations and treatments.