Coughing in the middle of the night needs to be treated according to the specific cause. The common causes of cough in the middle of the night are cough variant asthma, respiratory tract infections, physical and chemical factors, gastroesophageal reflux, postnasal drip syndrome. 1. Cough variant asthma: a special type of bronchial asthma, cough is the only or main symptom, mostly cough in the morning and at night, you can use salbutamol, terbutaline, budesonide formoterol powder inhaler and other bronchodilators to improve symptoms. 2. Respiratory tract infection: viral or bacterial attack triggers respiratory tract infection, which can also be manifested as cough in the middle of the night, such as sputum is relatively little or no sputum, sleep is seriously affected, dextromethorphan can be used to stop coughing; such as sputum and sputum expectoration difficulties, expectorant drugs can be used, usually aminobromine hydrochloride; combined with bacterial infections, can be used, such as cefixime. 3. Physical and chemical factors: for example, inhalation of irritating gases in the middle of the night may cause coughing, and the symptoms can usually be improved by removing the symptoms from the environment. 4. Gastroesophageal reflux (GERD): When cough symptoms occur, the key lies in the treatment of the original disease, such as the application of acid-suppressing drugs such as omeprazole and avoiding satiety before going to bed. 5. Postnasal drip syndrome: nasal secretions flow into the pharynx, stimulate the trachea, can also appear in the middle of the night cough, need to address the cause of treatment, such as chronic rhinitis and other causes, can be given fluticasone propionate nasal spray and other drug therapy. There are many other causes of coughing in the middle of the night, you need to see a doctor as soon as possible to clarify the cause, give targeted treatment, the above drugs need to be standardized under the guidance of a professional physician and pharmacist, rational application.