Tetanus immunoglobulin (TIG) is mainly used for the prevention and treatment of tetanus, and the injection of TIG does not usually lead to HIV infection. HIV is transmitted through blood, sex, and vertical transmission from mother to child, but can also be transmitted in other ways such as sharing needles, or through injections and dental extractions in unregulated medical facilities. If tetanus immunoglobulin is injected in a regular hospital, it is usually not possible to get infected with HIV. If symptoms such as nausea, vomiting and swollen lymph nodes occur after receiving tetanus immunoglobulin, it is recommended to consult a doctor in time, and under the doctor’s guidance, complete the relevant examinations to clarify the cause of the disease and provide symptomatic treatment.