The itchy sides of the buttocks may be caused by hives, eczema and other factors. Patients can be treated with oral or topical medications under the guidance of a doctor to clarify the cause of the disease. 1. Urticaria: Urticaria usually manifests itself in the form of a windy mass of varying sizes, which can be accompanied by a feeling of intense itching. In the treatment, you can take oral antihistamines, such as levocetirizine hydrochloride, olopatadine hydrochloride and so on, and you can also use topical glycerite lotion. 2. Eczema: Eczema is usually caused by allergic factors, there is obvious oozing patients can be used externally boric acid solution for wet compresses, after the rash is dry, you can also use glucocorticosteroid drugs, such as hydrocortisone butyrate, dinexed cream and so on. When the patient’s itchy buttocks on both sides, it is recommended to go to the hospital in time for examination, to clarify the cause of the disease, and then under the guidance of the doctor for medication.