Cold and heat mixed (the same patient at the same time the appearance of cold and heat evidence) can be divided into surface cold and heat, surface heat and cold, on the heat under the cold (the upper part of the heat, the lower part of the cold), on the cold under the heat and so on, the clinical manifestations of the different types of different certificates are different. 1. Cold on the surface and heat in the inside: clinical manifestations are cold (fear of cold) fever, no sweat, head and body pain, thirst and drink, irritability, constipation, yellow urine, red tongue with yellow fur, and so on. 2. Heat from the surface and cold from the inside: clinical manifestations include fever, cold, sweating, headache and sore throat, loose urine and loose stools, abdominal distension and fullness. 3. Upper heat and lower cold: the patient has both upper-anxiety heat (irritability and sultriness), sore throat and dry mouth, frequent vomiting and other upper-anxiety heat symptoms, and abdominal pain and warmth, loose stools and other spleen and stomach cold (spleen and stomach weakness and cold) symptoms. 4. Cold at the top and heat at the bottom: the patient has cold pain in the stomach and epigastric region, vomiting and salivation, etc., as well as damp-heat in the bladder, such as frequent urination, painful urination and short yellow urine. If there is any of the above discomfort, timely medical treatment is recommended.