The basic principle of pelvic organ prolapse (POP) surgery is “3R”, i.e. repair, restoration and reconstruction. There are three categories of organ prolapse caused by pelvic floor injury: i. Anterior pelvic defects: high mobility of urethra, subluxation of urethra, central anterior bikini defects, paravaginal defects, transverse vaginal defects, and site-specific defects; ii. Middle pelvic defects: uterine/vault prolapse, tau fossa hernia, bowel bulge, bladder bulge with uterine prolapse, and total pelvic prolapse; iii. Posterior pelvic defects: anatomical changes such as posterior vaginal wall prolapse, genital fissure widening, perineal central tendon separation, and rectal hernia. Reconstructive pelvic surgery (RPS) is divided into two categories: first, self-reinforced tissue repair. Second, Graft material repair. The reconstructive pelvic surgery includes anterior Pelvic Floor Repair, Stress Urinary Incontinence (SUI) treatment, Vaginal Vault Prolapse (Uterine Prolapse) Suspension Repair, Posterior Pelvic Floor Repair, and Le Fort closure. The vaginal wall is closed. About 30% of patients require reoperation due to recurrence of the prolapse due to their own tissue defects. More and more patients are opting for graft material for pelvic organ prolapse repair, vulvoplasty and vaginal renovation. Graft materials for pelvic floor repair and reconstruction surgery: At present, the graft materials used for pelvic floor repair and reconstruction surgery broadly include biological materials and synthetic materials, with transvaginal mesh being the latter. There are three types of biologic materials: self-graft materials (own donor, broad fascia, rectus abdominis fascia), homograft materials (donor is human, cadaveric broad fascia, dermis), and xenograft materials (donor is animal, pig, cow). Each graft material has its own advantages and disadvantages: (1) SYNTHETIC MATERIALS: solid, firm and convenient. Infection, erosion, rejection. (2) biological materials: self-graft materials (no rejection and erosion, but easy to recur) allograft materials (no rejection and erosion, poor tension) xenograft materials (minimal rejection and erosion, possible infection) biologic materials among the decellularized xenograft extracellular matrix (alloderm) is the best, and has been widely used in gynecological pelvic floor reconstruction surgery and It has been widely used in gynecological pelvic floor reconstruction surgery and vaginal reconstruction surgery, urethral reconstruction surgery, dental surgery, skin graft donor area coverage, intestinal fistula repair, etc. In cosmetic surgery, it is widely used in breast, nose, earlobe, lip, cleft lip and palate, maxillofacial, nasolabial folds, temporal, chin, interbrow, and periocular areas. In 2008 and 2011, the FDA issued two safety alerts regarding complications arising from the implantation of transvaginal mesh (mesh). The main points were that it is not uncommon for serious complications to occur with transvaginal mesh repair of pelvic floor prolapse, and that the results of transvaginal mesh repair for pelvic floor prolapse are no more effective than those of pelvic floor reconstruction without mesh. The current status of application in China is that vaginal mesh implantation with the application of kit devices is still developing rapidly. The International Urogynecologic Association (IUGA) Graft Forum suggests that synthetic mesh “may be effective” for: age >50 years, recurrent prolapse, bladder prolapse >II, intra-abdominal pressure elevation, and fascial defects.