Uterine fibroids pressing on the endometrium can be treated with medication or surgery according to the actual situation of the patient. 1. Medication: If the uterine fibroids compress the endometrium and cause abnormal menstruation, such as increased menstrual flow, prolonged menstrual period or menstrual disorders, etc., you can take the medication to reduce the size of uterine fibroids under the guidance of professional gynecologists, and the commonly used medications include mifepristone, goserelin or leuprolide, etc. However, mifepristone has relatively big side effects, and it should not be used in a long period of time. 2. Surgery: If the fibroid is seriously pressing on the endometrium, and the effect of medication is not obvious, we should consider surgery to remove the fibroid, which is suitable for patients who have no need for childbearing. If the fibroid is malignant, it is necessary to consider hysterectomy in combination with professional doctor’s opinion. If the uterine fibroid presses on the endometrium, it will cause abnormal menstruation, it is recommended to go to the regular hospital as soon as possible for consultation and treatment, and consider surgical treatment if necessary.