High microalbumin itself does not cause generalized weakness, the disease causing high microalbumin may cause generalized weakness. If high urinary microalbumin is caused by diabetic nephropathy, hypertensive nephropathy, lupus nephritis and other diseases, it will lead to generalized weakness. 1. Diabetic nephropathy: Patients with diabetic nephropathy undergo urine protein test and will have increased urine microalbumin. Diabetic nephropathy will lead to edema, hypertension, and anemia manifestations such as weakness and pallor. If diabetic nephropathy causes high urine microalbumin, generalized weakness may occur. 2. Hypertensive nephropathy: patients with hypertensive nephropathy will have generalized weakness, generalized soreness, proteinuria, increased nocturia and other manifestations. Patients will have increased urinary microalbumin when performing urine protein test. 3. Systemic lupus erythematosus: Systemic lupus erythematosus will lead to kidney damage, and patients will have increased urinary microalbumin in urine protein test. Patients with SLE may show weakness, fatigue, fever, as well as edema, hematuria, etc., so patients will have symptoms of general weakness. It is recommended that patients with high urinary microalbumin and generalized weakness should consult a doctor in time to find out the cause of the disease and follow the doctor’s instructions for treatment.