The first time you take Dapoxetine you need to pay attention to: you must have a doctor’s permission, avoid antecedents and alcohol, start with the smallest dose, be aware of the occurrence of side effects. 1. Doctor’s permission is required: Dapoxetine is not allowed to be used in patients with obvious pathological conditions of the heart (e.g. heart failure), taking monoamine oxidase inhibitors, taking strong cytochrome P4503A4 inhibitors such as ketoconazole, saquinavir, etc., with moderate or severe liver injury, or in women; in order to avoid injuries caused by incorrect use of the medication, the first time of using the medication is required to have a doctor’s permission. 2. Avoid prodromal symptoms and alcohol consumption: when taking Dapoxetine for the first time, patients should avoid prodromal symptoms such as fainting and dizziness, because this drug will aggravate these symptoms, in addition, patients also need to avoid contact with alcohol or its products when using the drug, because when taken with alcohol, it is possible to aggravate the adverse reactions of the neurocardiovascular system (e.g. fainting). 3. Start with the smallest dose: For all patients, it is recommended to start with the smallest dose of Dapoxetine for the first time, and then adjust the dosage according to the situation after the use of the drug. 4. Pay attention to the occurrence of side effects: some patients may experience side effects such as headache and dizziness, nausea and diarrhea, insomnia and fatigue when taking Dapoxetine for the first time, once the side effects are serious, go to the hospital in time. Dapoxetine is suitable for patients aged 18 to 64 years old with premature ejaculation, during the use of medication, patients need to strictly follow the doctor’s instructions.