Entecavir belongs to the antiviral drugs, patients taking entecavir can not cause liver cancer, on the contrary, entecavir can slow down the progression of hepatitis B to cirrhosis, thus reducing the chances of developing liver cancer. Entecavir is an antiviral drug used for the treatment of chronic adult hepatitis B with active viral replication, persistent elevation of serum alanine aminotransferase, or active lesions shown by liver histology, among others. Hepatocellular carcinoma refers to malignant tumors of the liver, hepatocellular carcinoma development is related to hepatitis viruses, cirrhosis, aflatoxin, certain chemical carcinogens, as well as soil and water, etc. Secondary hepatocellular carcinoma is caused by tumors of other organs metastasized to the liver. Patients taking entecavir will not develop hepatocellular carcinoma, on the contrary, it can stop the occurrence of hepatocellular carcinoma to a certain extent.