The normal value of total bilirubin is 3.4-17.1μmol/L. Total bilirubin 22.5 is high, and elevated bilirubin may be related to physiological factors such as alcohol consumption, high-fat diet, etc., or pathological factors such as hepatitis, etc., which need to be further investigated by a doctor, and should be actively treated if it is caused by pathological factors. Total bilirubin 22.5 is greater than the normal value, first of all, we should exclude physiological factors, whether recently drinking too much alcohol, eating a lot of fat substances, pay attention to the diet on the light, quit drinking, usually can effectively improve the symptoms. Elevated total bilirubin may also be related to liver disease, such as hepatitis, biliary obstruction, need to consult a doctor to identify the cause of the disease, but also need to be combined with aminotransferases, imaging, and the patient’s symptoms and signs to make a comprehensive judgment. Total bilirubin elevation alone is not clinically significant, we need to further improve the relevant examination, to identify the cause of the disease, under the guidance of the doctor to actively treat, to avoid further development of the disease.