Gastric sinus elevation erosion weight loss need to do gastroscopic pathology examination to exclude the possibility of gastric cancer or comorbidities, according to the specific circumstances of the drug treatment. Gastric sinus elevation erosion is erosive gastric sinusitis, clinical manifestations of abdominal distension, abdominal pain, acid belching and other symptoms of indigestion, but also may be due to loss of appetite, eating less and other factors lead to weight loss. When doing gastroscopy, it is necessary to take the tissue of the bulging erosion for pathological biopsy under the gastroscope to determine whether it is cancer in the gastric sinus area. Secondly, it is also necessary to improve the thyroid function test or blood glucose monitoring to clarify whether there is a combination of hyperthyroidism, diabetes mellitus and other causes of weight loss. According to the specific situation, the combination of drug and surgical treatment. If it is simple erosive gastro-sinusitis, it can be treated by drugs that inhibit gastric acid secretion and protect the gastric mucosa. After the celiac disease is relieved, the patient’s appetite improves and weight is slowly regained. In addition, it can be checked whether there is Helicobacter pylori infection and treated with antibiotics if necessary. Patients are advised to go to the hospital in time if they have any discomfort, avoid stimulating food in their daily diet, and eat more soft food. Live a regular life and do not overwork.