Chest discomfort and coughing during sleep may be caused by chronic bronchitis, bronchial asthma, bronchiectasis, gastroesophageal reflux disease, cardiac insufficiency and so on. 1. Chronic bronchitis: Chronic bronchitis should be treated in stages; during the acute attack period, we should actively control the infection, calm the wheezing and expectorate; during the remission period, we should mainly keep away from the triggering factors and cultivate a healthy lifestyle. 2. Bronchial asthma: medication is the main treatment program to deal with bronchial asthma, commonly used leukotriene modulators such as montelukast and other agents, formoterol, terbutaline and other beta agonists and so on. 3. Bronchodilatation: Patients with bronchodilatation can be treated with antimicrobials such as moxifloxacin and ampicillin for anti-infective purposes, as well as bronchodilators such as formoterol and ipratropium bromide. Also available are treatments such as postural drainage and nebulized inhalation. 4. Gastroesophageal Reflux Disease (GERD): GERD can lead to chest discomfort and coughing during sleep due to reflux of gastric contents. Acid-suppressing agents such as omeprazole and famotidine can be used, as well as surgical treatments such as fundoplication. 5. Cardiac insufficiency: the development of cardiac insufficiency is likely to lead to lung stasis, so the patient is likely to have chest discomfort and coughing in bed, the patient needs to be treated according to the cause of the disease, such as valvular disease can be used for valve replacement, coronary heart disease can be used for coronary artery bypass grafting or interventional therapy, and severe end-stage can be considered heart transplantation. Chest discomfort and coughing while sleeping, need to go to the hospital in time to identify the cause, under the guidance of the doctor standardized treatment.