A little discomfort below the heart fossa is mostly caused by angina pectoris due to cardiovascular system diseases and epigastric discomfort due to digestive system diseases. It needs to be treated for different causes. 1. Angina: Coronary heart disease is the most common cause of angina pectoris, which requires medication, including nitroglycerin, isosorbide nitrate, aspirin, clopidogrel, atorvastatin, resuvastatin and so on, which should be applied under the guidance of a doctor. In severe cases, surgical treatment is required, including coronary stenting and coronary artery bypass grafting. In addition, hypertrophic cardiomyopathy, aortic stenosis and other diseases can also cause angina pectoris. Hypertrophic cardiomyopathy can be treated with medication, such as bisoprolol, verapamil, etc. If the medication is ineffective, surgical resection of the interventricular septum can be considered; aortic stenosis with replacement of the aortic valve is the first choice for treatment. 2. Gastrointestinal diseases: mostly caused by peptic ulcer, reflux esophagus disease, gastritis, etc. For the epigastric discomfort caused by the above mentioned diseases, gastric mucosa protection drugs, such as aluminum thioglycollate, aluminum hydroxide, etc.; acid inhibitors, such as omeprazole, rabeprazole, etc., can be used to alleviate the symptoms. Drugs should be applied under the guidance of a doctor, if the effect is not good, please consult the doctor in time. It is recommended to consult the hospital to clarify the cause of the disease and treat it under the guidance of the doctor.