There is no such thing as which time of the day is the best time to take folic acid, folic acid can be taken at any time of the day. In addition, people with poor gastrointestinal function should not take folic acid on an empty stomach, and pregnant women with heavy reaction to vomiting need to take folic acid half an hour after meals. Folic acid is mainly used to treat megaloblastic anemia caused by folic acid deficiency, chronic hemolytic anemia caused by folic acid deficiency, or other reasons for the body to lack folic acid. In addition, women during pregnancy need folic acid to prevent fetal neurological defects and malformations. There is no clear clinical rule on the time to take folic acid, and folic acid can be taken at any time of the day. However, folic acid may irritate the gastrointestinal tract, and it is recommended that people with poor gastrointestinal function avoid taking folic acid on an empty stomach. If a pregnant woman has a severe early pregnancy reaction, she may choose to take folic acid half an hour after a meal. It is recommended that patients should follow the doctor’s instructions to eat folic acid, not unauthorized medication. And some patients may have nausea, bloating, fear of food and other uncomfortable reactions after taking folic acid for a long time, and if the patient eats a large amount of folic acid, the urine may be yellow. A few patients eating folic acid will have allergic reactions such as itchy skin and breathing difficulties. In addition, patients with pernicious anemia and vitamin B12 deficiency should not be treated with folic acid alone.