Wandering pain in the calf muscle may be caused by physiological reasons such as overwork, or it may be caused by pathologic reasons such as neuropathy, myofasciitis, rheumatic diseases and so on. 1. Overexertion: patients may feel wandering pain in calf muscles due to over-activity causing calf muscle exertion and accumulation of metabolic products. 2. Neuropathy: commonly seen in lumbar disc herniation or pear-shaped muscle syndrome, causing sciatic nerve compression or inflammation of the sciatic nerve and other lesions, the patient may experience calf muscle wandering pain, numbness and restricted movement and other symptoms. 3. Myofasciitis: due to long-term strain injury caused by local fascia, muscle and other tissues of aseptic inflammation, patients may appear calf muscle wandering pain. 4. Rheumatic diseases: common rheumatoid arthritis caused by the whole body acute or chronic connective tissue inflammation, patients may appear calf muscle pain. Calf muscle wandering pain patients are advised to consult a doctor in a timely manner to clarify the cause of the disease, under the guidance of the doctor for targeted treatment.