Getting up in the morning with pain in the middle of the chest may be heart disease, digestive system disease, respiratory system disease and chest wall disease. 1. Heart disease, chest pain in the morning, may be caused by coronary heart disease, myocardial ischemia and other diseases, often combined with hypertension, diabetes, hyperlipidemia and other diseases, the symptoms may be further aggravated. 2. Digestive system diseases, gastric acid reflux in the morning can also cause this symptom, mostly seen in reflux esophagitis, esophageal hiatal hernia and other diseases. 3. Respiratory diseases, this symptom will appear when there is inflammation or other lesions in the local or peripheral parts of the chest, which is common in pneumothorax, pulmonary embolism, pneumonia, pleural effusion and other diseases. 4. Chest wall diseases, ribs and surrounding soft tissue lesions can also appear chest pain, such as: costochondritis and so on. It is recommended to consult a doctor in time for targeted treatment under the guidance of a professional physician.