Xenadrine is known generically as Progesterone Vaginal Extended-Release Gel. The adverse effects of this drug include diarrhea, so Progesterone Vaginal Extended-Release Gel can cause diarrhea. Its incidence is more than 5%, and it is recommended to stop the drug and seek medical attention for severe diarrhea. Progesterone Vaginal Extended-Release Gel is mainly used for supplemental treatment of progesterone in assisted reproduction techniques, and its common adverse reactions include diarrhea, headache, nausea, joint pain, vaginal irritation, etc. These adverse reactions are relatively common and usually disappear after stopping the drug, but do not stop the drug without authorization, it is recommended to go to the hospital in a timely manner, symptomatic treatment, and if the symptoms are serious, it may be appropriate to change the drug or discontinue the drug. The drug is for external vaginal use, prohibited oral use, also prohibited and other vaginal preparations used at the same time. For drug allergy, the cause of the disease has not been identified. Vaginal bleeding, hepatic insufficiency, luteinizing hormone-sensitive malignant tumors, acute porphyria, thrombophlebitis, thrombotic disorders bleeding disorders, induced abortion, lactation, children are prohibited. The occurrence of diarrhea and other adverse reactions, it is recommended to promptly go to the hospital; the drug needs to be used under the guidance of a clinician.